| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:L 656748
CAS:121124-29-6
Purity:>99% by HPLC Package:1mg;5mg
|
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:Emamectin B1a
CAS:121124-29-6
Purity:>99% by HPLC Package:1mg;5mg
|
L 656748 manufacturers
- Emamectin B1a
-
- $1439.00
-
2026-04-21
- CAS:121124-29-6
- Purity:
- Supply Ability: 10g
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| | L 656748 Basic information |
| Product Name: | L 656748 | | Synonyms: | L 656748;Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-;Unii-IX4GP7848F;Emamectin B1a 100 μg/ml in Acetonitrile;Emamectin B1a in Acetonitrile;Avermectin impurity 17 monomer;Abamectin Impurity 17 Monomer;EMaMectin B1a | | CAS: | 121124-29-6 | | MF: | C49H75NO13 | | MW: | 886.12 | | EINECS: | | | Product Categories: | | | Mol File: | 121124-29-6.mol |  |
| | L 656748 Chemical Properties |
| Boiling point | 935.0±65.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, protect from light | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid | | pka | 12.42±0.70(Predicted) | | Stability: | Light Sensitive |
| | L 656748 Usage And Synthesis |
| Description | Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically. | | Uses | Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. | | References | [1] H. MROZIK. Discovery of novel avermectins with unprecedented insecticidal activity[J]. Experientia. Supplementum, 1989, 42 1: 315-316. DOI: 10.1007/bf01951823
[2] G R DAWSON. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2000, 295 3: 1051-1060.
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| | L 656748 Preparation Products And Raw materials |
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