- Fadrozole
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- $64.00 / 10mg
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2026-04-21
- CAS:102676-47-1
- Min. Order:
- Purity: 99.47%
- Supply Ability: 10g
- FADROZOLE USP/EP/BP
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- $1.10 / 1g
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2025-11-18
- CAS:102676-47-1
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Fadrozole
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- $0.00 / 1Kg
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2020-05-03
- CAS:102676-47-1
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 800 ton
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| | FADROZOLE Basic information |
| Product Name: | FADROZOLE | | Synonyms: | FADROZOLE;4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine-5-yl)benzonitrile;4-[(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin)-5-yl]benzonitrile;4-[[5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin]-5-yl]benzonitrile;5,6,7,8-Tetrahydro-5-(4-cyanophenyl)imidazo[1,5-a]pyridine;CGS-16949;Fadrozole Hydrochloride Hydrate;Afema | | CAS: | 102676-47-1 | | MF: | C14H13N3 | | MW: | 223.27 | | EINECS: | | | Product Categories: | | | Mol File: | 102676-47-1.mol |  |
| | FADROZOLE Chemical Properties |
| | FADROZOLE Usage And Synthesis |
| Chemical Properties | Melting point 117-118°C.
Fadrozole Hydrochloride: C14H13N3·HCl. [102676-96-0]. Crystallized from isopropyl alcohol, melting point 231-233°C. Soluble in water. | | Uses | Antineoplastic | | Definition | ChEBI: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile is an imidazopyridine. | | in vivo | Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED50 of 30 mg/kg when given orally[1]. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats[2]. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values[3]. | | IC 50 | Aromatase |
| | FADROZOLE Preparation Products And Raw materials |
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