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LABTER PHARMATECH(BEIJING) CO.,LTD
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| Products Intro: |
Product Name:6,7-DICHLOROCHROMAN-4-ONE
CAS:27407-06-3
Purity:95% HPLC Package:1g;5g;10g;25g;100g;250g;500g;1kg
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Shanghai Anmike Chemical Co. Ltd.
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微信 17321281695 18019252918 |
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sale@amkchem.com |
| Products Intro: |
Product Name:6,7-DICHLOROCHROMAN-4-ONE
CAS:27407-06-3
Purity:97% Package:1g,100g,1kg
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| Company Name: |
Shanghai CR Corporation Limited
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13062833949; 4006653949 4006653949 |
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fred.wen@crcorporation.cn |
| Products Intro: |
Product Name:6,7-DICHLOROCHROMAN-4-ONE
CAS:27407-06-3
Purity:98+ Package:1g/瓶
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Biokitchen
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021-021-021-31663258 13795219287 |
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| Products Intro: |
Product Name:6,7-Dichlorochroman-4-one
CAS:27407-06-3
Purity:> 97% HPLC Package:10G;100G；500G；1KG; 5KG, 10KG; 100KG
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| | 6,7-DICHLOROCHROMAN-4-ONE Basic information |
| | 6,7-DICHLOROCHROMAN-4-ONE Chemical Properties |
| Melting point | 131-132 °C(Solv: ligroine (8032-32-4)) | | Boiling point | 361.6±42.0 °C(Predicted) | | density | 1.469±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | Appearance | Off-white to light yellow Powder |
| | 6,7-DICHLOROCHROMAN-4-ONE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 6,7-dichlorochroman-4-one from 3-(3,4-dichlorophenoxy)propionic acid is as follows:
1. 500 mg of 3-(3,4-dichlorophenoxy)propionic acid was suspended in 50 mL of liquid hydrogen fluoride and the reaction system was cooled in a solid carbon dioxide/acetone bath.
2. The reaction mixture was stirred overnight, during which time the cooling bath was not replenished.
3. Upon completion of the reaction, the hydrogen fluoride is removed by a stream of air.
4. The residual solid is dissolved in ether and washed with 10% aqueous sodium carbonate.
5. The organic layer is separated and dried over anhydrous magnesium sulfate, followed by evaporation of the solvent to give 6,7-dichloro-2,3-dihydro-4-one (PCI 65C) of sufficient purity.
Product Characterization:
PCI 65C was an off-white solid, yield: 350 mg (76%).
1H NMR (CDCl3, 400 MHz) δ: 2.79 (t, 2H), 4.52 (t, 2H), 7.10 (s, 1H), 7.90 (s, 1H).
13C NMR (CDCl3, 100 MHz) δ: 37.4, 67.6, 118.0, 120.2, 120.9, 126.0, 128.3, 140.0, 160.3, 189.9. | | References | [1] Patent: WO2012/6068, 2012, A2. Location in patent: Page/Page column 104-105
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5094 - 5111 |
| | 6,7-DICHLOROCHROMAN-4-ONE Preparation Products And Raw materials |
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