Reaxys ID: 26778003 manufacturers
- PF-05388169
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- $1980.00
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2026-04-21
- CAS:1604034-78-7
- Purity:
- Supply Ability: 10g
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| | Reaxys ID: 26778003 Basic information |
| | Reaxys ID: 26778003 Chemical Properties |
| Boiling point | 640.7±55.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | pka | 13.42±0.40(Predicted) |
| | Reaxys ID: 26778003 Usage And Synthesis |
| Uses | IRAK4-IN-29 is an IRAK4 inhibitor with good selectivity and low nanomolar activity. IRAK4-IN-29 can effectively block the TLR-mediated signal transduction pathway. IRAK4-IN-29 showed significant inhibitory effects in LPS- and R848-induced cytokine experiments. IRAK4-IN-29 can inhibit LPS-induced TNFα in an in vivo model, showing a similar phenotype to IRAK4 gene-deficient mice. IRAK4-IN-29 has good medicinal chemical properties, such as microsomal stability and solubility, showing potential clinical application value[1]. | | References | [1] Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4 |
| | Reaxys ID: 26778003 Preparation Products And Raw materials |
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