GSK2190915 (sodiuM salt) manufacturers
- Fiboflapon sodium
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- $89.00 / 2mg
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2026-05-11
- CAS:1196070-26-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | GSK2190915 (sodiuM salt) Basic information |
| Product Name: | GSK2190915 (sodiuM salt) | | Synonyms: | GSK2190915 (sodiuM salt);GSK2190915 Sodium;GSK-2190915A;AM-803 sodium);Fiboflapon sodium;GSK2190915 sodium
(GSK-2190915A;FIBOFLAPON SODIUM;FIBOFLAPON SODIUM | | CAS: | 1196070-26-4 | | MF: | C38H44N3NaO4S | | MW: | 661.84 | | EINECS: | | | Product Categories: | | | Mol File: | 1196070-26-4.mol |  |
| | GSK2190915 (sodiuM salt) Chemical Properties |
| form | Powder | | color | White to off-white |
| | GSK2190915 (sodiuM salt) Usage And Synthesis |
| Uses | Fiboflapon sodium (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood[1]. | | IC 50 | LTB4: 76 nM (IC50) | | References | [1] Stock NS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. J Med Chem. 2011 Dec 8;54(23):8013-29. DOI:10.1021/jm2008369 [2] Lorrain DS, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. DOI:10.1016/j.ejphar.2010.05.003 |
| | GSK2190915 (sodiuM salt) Preparation Products And Raw materials |
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