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| | 4-AMINOBENZAMIDINE HYDROCHLORIDE Basic information |
| Product Name: | 4-AMINOBENZAMIDINE HYDROCHLORIDE | | Synonyms: | 4-aminobenzenecarboximidamidemonohydrochloride;4-amino-benzenecarboximidamidmonohydrochloride;p-aminobenzamidinehydrochloride;p-amino-benzamidinmonohydrochloride;TIMTEC-BB SBB003838;P-AMINOBENZAMIDINE HCL;4-AMINOBENZAMIDINE HYDROCHLORIDE;4-Aminobenzamidine monohydrochloride | | CAS: | 7761-72-0 | | MF: | C7H10ClN3 | | MW: | 171.63 | | EINECS: | | | Product Categories: | | | Mol File: | 7761-72-0.mol |  |
| | 4-AMINOBENZAMIDINE HYDROCHLORIDE Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature |
| | 4-AMINOBENZAMIDINE HYDROCHLORIDE Usage And Synthesis |
| Uses | 4-Aminobenzimidamide Hydrochloride (Compound 4a) is a MRGPRX1 agonist. 4-Aminobenzimidamide Hydrochloride can be used in the study of MRGPRX1-mediated analgesic effects[1]. | | Synthesis | 4-aminophenyl ethyl imino ether hydrochloride(3.0 g) was added to a solution of ammonia (12g) in ethanol(150ml, ~8% mass percent) with stirring at room temperature for 24 hours. The reaction mixture was filtered and concentrated in vacuo, and acidated with hydrochloric acid (5ml, 63%). Absorbent charcoal was used to purify. The mixture was filtered, and concentrated and dried in vacuo at room temperature to give 5.0 g(86%) of 4-aminobenzamidine hydrochloride was obtained as a bright yellow solid. | | References | [1] Prchalová E, et al. Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem. 2019 Sep 26;62(18):8631-8641. DOI:10.1021/acs.jmedchem.9b01003 |
| | 4-AMINOBENZAMIDINE HYDROCHLORIDE Preparation Products And Raw materials |
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