N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3

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N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:SB 216641 hydrochloride
CAS:193611-67-5
Purity:98.40% Package:1mg;68USD|5mg;168USD|10mg;249USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:SB 216641 hydrochloride
CAS:193611-67-5
Purity:>=98% Package:$59.9/1mg;$179.9/5mg;$226.9/10mg;$589.9/25mg;$950.9/50mg;Bulk package Remarks:98%
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Products Intro: Product Name:SB-216641 hydrochloride
CAS:193611-67-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
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Products Intro: Product Name:SB 216641 hydrochloride
CAS:193611-67-5
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Products Intro: Product Name:SB 216641 hydrochloride
CAS:193611-67-5
Purity:99% Package:1mg;5mg;10mg

N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 manufacturers
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Basic information
Product Name:N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
Synonyms:N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3;SB 216641A;SB 216641 hydrochloride, h5-HT1B antagonist;N-(3-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
CAS:193611-67-5
MF:C28H31ClN4O4
MW:523.03
EINECS:
Product Categories:
Mol File:193611-67-5.mol
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Structure
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Chemical Properties
storage temp. Store at RT
solubility DMSO: soluble; Water: soluble
form Powder
color White to off-white
Water Solubility Soluble to 50 mM in water
InChIKeyJPBMDMNORXKGHZ-UHFFFAOYSA-N
SMILESCC1C=C(C2=NOC(C)=N2)C=CC=1C1C=CC(C(=O)NC2C=CC(OC)=C(OCCN(C)C)C=2)=CC=1.Cl
Safety Information
MSDS Information
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Usage And Synthesis
UsesSB 216641 Hydrochloride is a selective SR-1B and 5-HT1B antagonist.
in vivo

SB-216641A (0.6-20 mg/kg; i.p.; single dose) hinders the SKF-99101H induced hypothermia with dose-dependent manner in guinea pigs[1].
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2].

Animal Model:Guinea pigs[1].
Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.
Administration:Intraperitoneal injection; single dose.
Result:Significantly blocked the effects of SKF-99101H.
Animal Model:Dogs[2].
Dosage:559 nmol/kg.
Administration:Intravenous injection; single dose.
Result:Improved the gastric relaxation.
IC 505-HT1B Receptor; 5-HT1D Receptor
storageStore at RT
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Preparation Products And Raw materials
Tag:N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3(193611-67-5) Related Product Information