| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | 4-Mercaptophenylacetic acid Basic information |
| | 4-Mercaptophenylacetic acid Chemical Properties |
| Melting point | 105-109 °C (lit.) | | Boiling point | 336.0±17.0 °C(Predicted) | | density | 1.299±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Acetonitrile (Slightly), DMSO (Slightly) | | pka | 4.21±0.10(Predicted) | | form | Solid | | color | Off-White | | Water Solubility | Slightly soluble in water. Soluble in Dichloromethane, Ethanol and Methanol | | Sensitive | Air Sensitive | | InChI | InChI=1S/C8H8O2S/c9-8(10)5-6-1-3-7(11)4-2-6/h1-4,11H,5H2,(H,9,10) | | InChIKey | ORXSLDYRYTVAPC-UHFFFAOYSA-N | | SMILES | C1(CC(O)=O)=CC=C(S)C=C1 |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-36/37/39 | | RIDADR | UN 3335 | | WGK Germany | 3 | | HS Code | 2930909899 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 4-Mercaptophenylacetic acid Usage And Synthesis |
| Chemical Properties | 4-MERCAPTOPHENYLACETIC ACID is White Powder | | Uses | 4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.
It can be used:
- On-resin preparation of peptide-α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.
- In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.
- Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins.
| | Uses | 4-MERCAPTOPHENYLACETIC ACID is a redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents. |
| | 4-Mercaptophenylacetic acid Preparation Products And Raw materials |
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