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| | 4-(TRIFLUOROMETHOXY)BENZYLAMINE Basic information |
| | 4-(TRIFLUOROMETHOXY)BENZYLAMINE Chemical Properties |
| Boiling point | 57-60 °C10 mm Hg(lit.) | | density | 1.252 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.452(lit.) | | Fp | 172 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 8.75±0.10(Predicted) | | form | Liquid | | Specific Gravity | 1.252 | | color | Clear colorless to light yellow | | Sensitive | Air Sensitive | | BRN | 8200624 | | CAS DataBase Reference | 93919-56-3(CAS DataBase Reference) |
| Hazard Codes | Xi,C | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39-37/39 | | RIDADR | UN2735 | | WGK Germany | 3 | | Hazard Note | Corrosive | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29222990 |
| | 4-(TRIFLUOROMETHOXY)BENZYLAMINE Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow liquid | | Uses | 4-(Trifluoromethoxy)benzylamine may be used in chemical synthesis. | | Synthesis | A tetrahydrofuran (30 mL) solution of 4-(trifluoromethoxy)benzyl cyanide (5.0 g, 26.72 mmol) was slowly added dropwise to a tetrahydrofuran (30 mL) solution of lithium aluminum tetrahydroxide (3.0 g, 88.44 mmol) at 0 °C. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the mixture was cooled to 4 °C and diluted with tetrahydrofuran (50 mL). Subsequently, the reaction was quenched by sequentially adding water (3 mL), 15% sodium hydroxide solution (3 mL) and water (3 mL). After quenching, the mixture was stirred at room temperature for 15 minutes. The mixture was filtered through diatomaceous earth and the filtrate was dried with anhydrous magnesium sulfate. Finally, the filtrate was concentrated under reduced pressure to give 4-(trifluoromethoxy)benzylamine (3.1 g, 61% yield). | | References | [1] Patent: WO2017/139414, 2017, A1. Location in patent: Paragraph 00215-00216 |
| | 4-(TRIFLUOROMETHOXY)BENZYLAMINE Preparation Products And Raw materials |
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