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| | N-BOC-piperidine-4-carboxylic acid Basic information |
| | N-BOC-piperidine-4-carboxylic acid Chemical Properties |
| Melting point | 148-153 °C | | Boiling point | 353.2±35.0 °C(Predicted) | | density | 1.164±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 4.56±0.20(Predicted) | | form | Crystalline Powder | | color | White | | Water Solubility | Insoluble in water. | | BRN | 5533442 | | Major Application | peptide synthesis | | InChI | InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-8(5-7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14) | | InChIKey | JWOHBPPVVDQMKB-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCC(C(O)=O)CC1 | | CAS DataBase Reference | 84358-13-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids |
| | N-BOC-piperidine-4-carboxylic acid Usage And Synthesis |
| Chemical Properties | White crystalline powder | | Uses | It is a pharmaceutical intermediate. he camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug. | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | General procedure for the synthesis of 1-Boc-4-piperidinecarboxylic acid from methyl 1-Boc-4-piperidinecarboxylate: 4-tert-butyl-4-methylpiperidine-1,4-dicarboxylate (4.84 g, 20 mmol) and LiOH (2.52 g, 60 mmol) were reacted with 4-tert-butyl-4-methylpiperidine-1,4-dicarboxylate (4.84 g, 20 mmol) and LiOH (2.52 g, 60 mmol) in a mixture of THF (90 mL), MeOH (90 mL) and H2O (30 mL) in a solvent, and the reaction was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to pH 2 with aqueous 2N HCl. Subsequently, the reaction mixture was extracted with EtOAc (3 × 20 mL). The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (4.6 g, 100.0% yield). | | References | [1] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 56
[2] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0205; 0206
[3] Patent: US2016/102095, 2016, A1. Location in patent: Paragraph 0131
[4] Patent: CN104292233, 2016, B. Location in patent: Paragraph 0047
[5] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00538 |
| | N-BOC-piperidine-4-carboxylic acid Preparation Products And Raw materials |
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