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| | Tyrosine-protein phosphatase non-receptor type 11 Basic information |
| Product Name: | Tyrosine-protein phosphatase non-receptor type 11 | | Synonyms: | ANTI-SHP2 antibody produced in rabbit;Anti-SHP-2, C-Terminal antibody produced in rabbit;Anti-SH-PTP2 antibody produced in rabbit;Tyrosine-protein phosphatase non-receptor type 11;Protein-tyrosine phosphatase 1D;PTP2C;PTPN11;SHPTP2 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Tyrosine-protein phosphatase non-receptor type 11 Structure]() |
| | Tyrosine-protein phosphatase non-receptor type 11 Chemical Properties |
| storage temp. | -20°C | | form | aqueous solution | | biological source | rabbit |
| WGK Germany | 1 | | Storage Class | 10 - Combustible liquids |
| | Tyrosine-protein phosphatase non-receptor type 11 Usage And Synthesis |
| Uses | Useful for the study of enzyme kinetics, regulation, to dephosphorylate target substrates and for screening inhibitors.
Human active SHP-2 has been used to study the effects of α-lipoic acid and dihydrolipoic acid on the activity of SHP-2 enzyme. | | General Description | Protein tyrosine phosphatase, non-receptor type 11 (PTPN11), also known as SHP-2, is a scaffolding protein. It possesses two SH2 domains at the amino terminal, a protein tyrosine phosphatase domain and carboxy-terminal region. The gene encoding SHP-2 is localized on human chromosome 12q24.13. | | Biochem/physiol Actions | Protein tyrosine phosphatase, non-receptor type 11 (PTPN11) or SHP-2 is involved in signal transduction pathways downstream of growth receptors. It acts as a proto-oncogene. SHP-2 leads to sustained RAS activation by dephosphorylating the RAS-GTPase-activating protein binding site on Grb2-associated binder 1 (Gab1). This protein also nucleates multiple signaling proteins and thus, acts as an adaptor protein. Mutations in the SHP-2 gene have been associated with Noonan syndrome. |
| | Tyrosine-protein phosphatase non-receptor type 11 Preparation Products And Raw materials |
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