- 1,2,3-1H-Triazole
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- $0.00 / 25KG
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2025-08-08
- CAS:288-36-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- 1,2,3-1H-Triazole
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- $0.00 / 1KG
-
2025-06-27
- CAS:288-36-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
- 1,2,3-1H-Triazole
-
- $10.00 / 1KG
-
2025-06-24
- CAS:288-36-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
Related articles - Synthesis, Properties, Chemical Reactivity of 1,2,3-Triazole
- 1,2,3-Triazole is an unsaturated, aromatic, five-membered, π-excessive nitrogen heterocycle with a 6π electron ring system, c....
- Feb 14，2022
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| Product Name: | 1,2,3-1H-Triazole | | Synonyms: | LABOTEST-BB LT02056574;1H-1,2,3-TRIAZOLE;1,2,3-TRIAZOLE;1,2,3-1H-TRIAZOLE;TRIAZOLE(1,2,3-);1,2,3-Triazol;1H-1,2,3-Triazol;Osotriazole | | CAS: | 288-36-8 | | MF: | C2H3N3 | | MW: | 69.07 | | EINECS: | 608-262-3 | | Product Categories: | Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;Heterocyclic Building Blocks;Triazoles;bc0001 | | Mol File: | 288-36-8.mol |  |
| | 1,2,3-1H-Triazole Chemical Properties |
| Melting point | 23-25 °C(lit.) | | Boiling point | 203 °C752 mm Hg(lit.) | | density | 1.192 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.498(lit.) | | Fp | 225 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Acetone, Chloroform, Methanol (Slightly) | | form | Liquid | | pka | 1.17(at 20℃) | | color | Clear colorless to yellow | | Specific Gravity | 1.192 | | Water Solubility | soluble | | FreezingPoint | 21.0 to 24.0 ℃ | | BRN | 104766 | | InChIKey | QWENRTYMTSOGBR-UHFFFAOYSA-N | | CAS DataBase Reference | 288-36-8(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-1,2,3-Triazole(288-36-8) |
| | 1,2,3-1H-Triazole Usage And Synthesis |
| Description | 1,2,3-1H-Triazole is a kind of azole compound. It can effectively promote the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. It is also a useful triazole for proteomics research1. It also find use in research as a bioisostere in medicinal chemistry as well as an building block for more complex chemical compounds, including pharmaceutical drugs such as mubritinib and tazobactam2. It is a main class of hetero-cycles because of its extensive range of biological properties such as antimicrobial, anticancer, anti-tubercular, anti-HIV, antimalarial, antibacterial, antifungal, antiviral and anti-diabetic property3.
| | Chemical Properties | clear colorless liquid | | Uses | A basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifunga
l, antibacterial and antiviral activities in bioactive triazoles. | | Uses | It effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. A useful triazole for proteomics research | | Definition | ChEBI: 1H-1,2,3-triazole is a 1,2,3-triazole. It is a tautomer of a 2H-1,2,3-triazole and a 4H-1,2,3-triazole. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 62, p. 9177, 1997 DOI: 10.1021/jo971313o | | General Description | 2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. | | Synthesis | General procedure for the synthesis of 1,2,3-triazole from 1H-1,2,3-triazole-4,5-dicarboxylic acid: to a 2000 mL four-neck flask was added 1250 mL of pure water and 157.08 g (1.0 mol) of 1H-1,2,3-triazole-4,5-dicarboxylic acid, followed by the addition of 4.71 g (equivalent to 1H-1,2,3-triazole-4,5-dicarboxylic acid 3% by mass) of N,N-diisopropylethylamine. The reaction mixture was heated to 100~110°C under atmospheric pressure and refluxed until the reaction solution was clarified. Refluxing was continued for 1 h. The reaction was monitored by HPLC and terminated when the residue of 1H-1,2,3-triazole-4,5-dicarboxylic acid was less than 1%. After completion of the reaction, filtration was performed. A vacuum pump was used to remove most of the water from the filtrate, which was then replaced with a mechanical pump for high vacuum dehydration. The four-necked flask was mounted on a distillation apparatus and vacuum distillation was carried out, resulting in 66.48 g of 1H-1,2,3-triazole with a molar yield of 96.25% and a GC purity of 99.56%. | | References | [1] Patent: CN106946803, 2017, A. Location in patent: Paragraph 0035; 0040; 0041; 0045; 0046; 0050; 0051
[2] Patent: CN105330607, 2016, A. Location in patent: Paragraph 0033; 0034
[3] Chemische Berichte, 1893, vol. 26, p. 2737 |
| | 1,2,3-1H-Triazole Preparation Products And Raw materials |
| Raw materials | 1,2,3-TRIAZOLE-4-CARBOXYLIC ACID-->1,2,3-TRIAZOLE-4,5-DICARBOXYLIC ACID-->N,N-Diisopropylethylamine | | Preparation Products | 3H-Azirine-->3-(1H-1,2,4-TRIAZOL-1-YL)PROPANOIC ACID-->5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid-->2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid-->FLUCONAZOLE IMPURITY C-->4,5-DIBROMO-1H-1,2,3-TRIAZOLE-->1H-Isoindole-1,3(2H)-dione, 2-[2-(1H-1,2,3-triazol-1-yl)ethyl]- |
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