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| | 5-Fluoro-2-methylindole Basic information |
| | 5-Fluoro-2-methylindole Chemical Properties |
| Melting point | 98-101 °C (lit.) | | Boiling point | 112-120C | | density | 1.219±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Solid | | pka | 16.73±0.30(Predicted) | | color | Light yellow to Brown | | InChI | InChI=1S/C9H8FN/c1-6-4-7-5-8(10)2-3-9(7)11-6/h2-5,11H,1H3 | | InChIKey | JJIUISYYTFDATN-UHFFFAOYSA-N | | SMILES | N1C2=C(C=C(F)C=C2)C=C1C | | CAS DataBase Reference | 399-72-4(CAS DataBase Reference) |
| Hazard Codes | Xi,T | | Risk Statements | 36/37/38-25 | | Safety Statements | 26-36-45-36/37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-Fluoro-2-methylindole Usage And Synthesis |
| Description | 5-Fluoro-2-methylindole is a chemical intermediate that can be used in the synthesis of other compounds. It is a versatile building block with many applications, such as being a useful intermediate for the synthesis of heterocyclic compounds. This compound reacts with aniline to form 2,6-diaminopyridine, which has been shown to have anti-inflammatory properties. | | General Description | 5-Fluoro-2-methylindole (5-Fluoro-2-methyl-1H-indole) is a 5-substituted-2-methyl-1H-indole. | | Synthesis | 1-(5-fluoro-2-nitrophenyl) propane-2-one (0.5mmol, 99 mg), zinc powder (3.0mmol, 196 mg), and acetic acid (6.0mmol, 360 mg) was added to the reaction tube, followed by adding ethanol to 2 ml at 90 °C for 3h. After cooling to room temperature, the reaction system was added 20 ml water. 5-Fluoro-2-methylindole was obtained after purification.  | | Solubility in water | Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform, Practically insoluble in water. | | References | [1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 44, p. 10511 - 10515
[2] Patent: CN106631968, 2017, A. Location in patent: Paragraph 0069-0072; 0074 |
| | 5-Fluoro-2-methylindole Preparation Products And Raw materials |
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