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EMMX Biotechnology LLC
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Product Name:BC 11-38
CAS:686770-80-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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BC 11-38 manufacturers
- BC 11-38
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- $64.00 / 5mg
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2026-01-05
- CAS:686770-80-9
- Min. Order:
- Purity: 98.95%
- Supply Ability: 10g
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| | BC 11-38 Basic information |
| Product Name: | BC 11-38 | | Synonyms: | 3-phenyl-2-(propylthio)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one;6,7-Dihydro-3-phenyl-2-(propylthio)thieno[3,2-d]pyrimidin-4(3H)one;Thieno[3,2-d]pyrimidin-4(3H)-one, 6,7-dihydro-3-phenyl-2-(propylthio)-;cortisol,adrenocortical,Phosphodiesterase (PDE),cAMP,BC 11 38,Inhibitor,production,inhibit,levels,cells,BC11-38,BC 1138;BC-11-38, PDE-11 inhibitor;BC 11-38, 10 mM in DMSO;BC-11-38,PDE-11 | | CAS: | 686770-80-9 | | MF: | C15H16N2OS2 | | MW: | 304.43 | | EINECS: | | | Product Categories: | | | Mol File: | 686770-80-9.mol |  |
| | BC 11-38 Chemical Properties |
| storage temp. | RT | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming). | | form | solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | BC 11-38 Usage And Synthesis |
| Description | BC-11-38 (686770-80-9) is a potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 μM).1 IC50s for PDE1-10 are greater than 100 μM. Restores the ability of p54nrb / NONOKD cells to generate cAMP in response to ACTH stimulation and the production of cortisol and DHEA in response to cAMP signaling.2 | | Uses | BC 11-38 is a selective inhibitor of phosphodiesterase 11. Potent PDE-11 inhibitor | | IC 50 | PDE10: >100 μM (IC50); PDE11: 0.28 μM (IC50) | | References | [1] OZGE CEYHAN Charles S H Kivanc Birsoy. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.[J]. Chemistry & biology, 2012, 19 1: 155-163. DOI:10.1016/j.chembiol.2011.12.010
[2] JIA YANG LU Marion B S. p54nrb/NONO regulates cyclic AMP-dependent glucocorticoid production by modulating phosphodiesterase mRNA splicing and degradation.[J]. Molecular and Cellular Biology, 2015, 35 7: 1223-1237. DOI:10.1128/mcb.00993-14 |
| | BC 11-38 Preparation Products And Raw materials |
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