1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one
| 中文名称 | 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one |
|---|---|
| 中文同义词 | 化合物 T24648;化合物 PK-THPP |
| 英文名称 | 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one |
| 英文同义词 | 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one;1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone;PK-THPP;1-Butanone, 1-[1-[6-([1,1'-biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-;PK-THPP >=98% (HPLC);PKTHPP,PK THPP |
| CAS号 | 1332454-07-5 |
| 分子式 | C29H32N4O2 |
| 分子量 | 468.59 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1332454-07-5.mol |
| 结构式 | ![1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one 结构式](CAS/20180629/GIF/1332454-07-5.gif) |
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | H2O: 10mg/mL, clear DMSO: 2mg/mL, clear (warmed) |
| InChI | 1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3 |
| InChIKey | CJZGRIRZVHNUSM-UHFFFAOYSA-N |
| SMILES | O=C(CCC)C(CC1)CCN1C2=C3C(CCN(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)C3)=NC=N2 |
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one 用途与合成方法
PK-THPP 是一种有效的 TASK-3 离子通道阻滞剂(对于 TASK-3 和 TASK-1，IC50s 分别为 35 nM 和 300 nM)。PK-THPP 增加大鼠的呼吸频率并诱导呼吸性碱中毒。
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |