- Urodilatin (human)
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- $65.00
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2026-08-25
- CAS:118812-69-4
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons
- Urodilatin (human)
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-
2026-07-15
- CAS:118812-69-4
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1000g
- Urodilatin (human)
-
- $20.00
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2025-06-20
- CAS:118812-69-4
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10 tons
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| | Urodilatin (human) Basic information |
| Product Name: | Urodilatin (human) | | Synonyms: | L-Tyrosine, L-threonyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenyla... | | CAS: | 118812-69-4 | | MF: | C145H234N52O44S3 | | MW: | 3505.97 | | EINECS: | 251-228-4 | | Product Categories: | | | Mol File: | 118812-69-4.mol |  |
| | Urodilatin (human) Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | Sequence | H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge Cys11-Cys27) | | InChIKey | IUCCYQIEZNQWRS-JVMWJOHJNA-N |
| | Urodilatin (human) Usage And Synthesis |
| Uses | Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5]. | | in vivo | Ularitide (10nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs[1]. | Animal Model: | Female dogs with or without surgically induced chronic aortocaval fistula[1] | | Dosage: | 5 and 10 pmol/kg/min | | Administration: | i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min. | | Result: | Increased in urine volume and sodium excretion with high-output CHF. |
| | References | [1] Anker SD, et al. Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
[2] Korn C, et al. Comparison of the effects of ularitide acetate and other bronchorelaxing substances on the thrombin-induced permeability raise of human endothelial cell monolayers. Arzneimittelforschung. 1998 Mar;48(3):251-8. PMID:9553682
[3] Nally JE, et al. Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: comparison with atrial natriuretic peptide. Br J Pharmacol. 1995 Apr;114(7):1391-6. DOI:10.1111/j.1476-5381.1995.tb13360.x
[4] Valentin JP, et al. Urodilatin binds to and activates renal receptors for atrial natriuretic peptide. Hypertension. 1993 Apr;21(4):432-8. DOI:10.1161/01.hyp.21.4.432
[5] Choi MR, et al. Urodilatin regulates renal dopamine metabolism. J Nephrol. 2013 Nov-Dec;26(6):1042-8. DOI:10.5301/jn.5000279 |
| | Urodilatin (human) Preparation Products And Raw materials |
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