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2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

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Products Intro: Product Name:2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)uridine
CAS:177980-10-8
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Products Intro: Product Name:2'-AZIDO-2'-DEOXY-5'-O-(4,4'-DIMETHOXYTRITYL)URIDINE
CAS:177980-10-8
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Products Intro: Product Name:2'-Azido-2'-deoxy-5'-O-DMT-uridine
CAS:177980-10-8
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Products Intro: Product Name:2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
CAS:177980-10-8
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Products Intro: Product Name:2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
CAS:177980-10-8
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2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Basic information
Product Name:2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine
Synonyms:2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine;2'-Azido-2'-deoxy-5'-O-DMT-uridine;2’-Azido-2’-deoxy-5’-O-(4,4’-dimethoxytrityl)uridine;2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
CAS:177980-10-8
MF:C30H29N5O7
MW:571.59
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Mol File:177980-10-8.mol
2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Structure
2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Chemical Properties
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2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Usage And Synthesis
Uses2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2′-Azido-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
2'-Azido-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine Preparation Products And Raw materials
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