- DHM; DIHYDROMETHYSTICIN
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- $0.00 / 20MG
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2026-01-23
- CAS:19902-91-1
- Min. Order: 20MG
- Purity: >95% HPLC
- Supply Ability: 1000KG
- Dihydromethysticin
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- $64.00 / 1mg
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2026-01-12
- CAS:19902-91-1
- Min. Order:
- Purity: 99.85%
- Supply Ability: 10g
- DIHYDROMETHYSTICIN
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- $9.80 / 1KG
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2020-01-13
- CAS:19902-91-1
- Min. Order: 1KG
- Purity: ≥98%
- Supply Ability: 20 tons
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| | DIHYDROMETHYSTICIN Basic information |
| Product Name: | DIHYDROMETHYSTICIN | | Synonyms: | 6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-2h-pyran-2-on(s);6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-(s)-2h-pyran-2-on;7,8-dihydromethysticin;dhm;DIHYDROMETHYLSTICIN;7,8-DIHYDROMETHYLSTICIN;5,6-Dihydro-4-methoxy-6-[2-(1,3-benzodioxol-5-yl)ethyl]-2H-pyran-2-one;6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one | | CAS: | 19902-91-1 | | MF: | C15H16O5 | | MW: | 276.28 | | EINECS: | | | Product Categories: | Coumarins | | Mol File: | 19902-91-1.mol |  |
| | DIHYDROMETHYSTICIN Chemical Properties |
| storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) | | Melting point | 117-118 °C | | density | 1.28±0.1 g/cm3(Predicted) | | form | Solid | | Boiling point | 476.1±45.0 °C(Predicted) | | color | White to Off-White | | BRN | 91699 | | Stability: | Hygroscopic | | Major Application | food and beverages | | InChI | InChI=1S/C15H16O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h3,5-6,8,11H,2,4,7,9H2,1H3/t11-/m0/s1 | | InChIKey | RSIWXFIBHXYNFM-NSHDSACASA-N | | SMILES | C1(=O)O[C@@H](CCC2=CC=C3OCOC3=C2)CC(OC)=C1 | | LogP | 1.810 (est) |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | DIHYDROMETHYSTICIN Usage And Synthesis |
| Description | Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg. | | Chemical Properties | White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Pipermethysticum Forst. | | Uses | (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant. | | Definition | ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether. | | IC 50 | CYP3 | | References | [1] D. D. JAMIESON P. H D. THE ANTINOCICEPTIVE ACTIONS OF KAVA COMPONENTS IN MICE[J]. Clinical and Experimental Pharmacology and Physiology, 1990, 17 7: 495-507. DOI: 10.1111/j.1440-1681.1990.tb01349.x
[2] CORD BACKHAUΒ Josef K. Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents[J]. European journal of pharmacology, 1992, 215 2: Pages 265-269. DOI: 10.1016/0014-2999(92)90037-5
[3] JOHANNA WEISS. Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.[J]. Drug Metabolism and Disposition, 2005, 33 11: 1580-1583. DOI: 10.1124/dmd.105.005892 |
| | DIHYDROMETHYSTICIN Preparation Products And Raw materials |
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