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| | Tetrachlorophthalic anhydride Basic information |
| | Tetrachlorophthalic anhydride Chemical Properties |
| Melting point | 253-257 °C(lit.) | | Boiling point | 371 °C(lit.) | | density | 1.49 | | vapor pressure | 0.16 mm Hg ( 145 °C) | | Fp | 362°C | | storage temp. | Store below +30°C. | | solubility | Chloroform (Slightly, Heated), DMSO (Heated), Methanol (Slightly, Heated) | | pka | 3.01[at 20 ℃] | | form | Flakes | | color | White to off-white | | Water Solubility | 0.8 mg/L (21 ºC) | | Sensitive | Moisture Sensitive | | BRN | 211560 | | Exposure limits | ACGIH: TWA 0.002 mg/m3 (Skin) | | Stability: | Stable. Reacts with water. Combustible. Incompatible with strong oxidizing agents. Air and moisture sensitive. | | InChI | 1S/C8Cl4O3/c9-3-1-2(8(14)15-7(1)13)4(10)6(12)5(3)11 | | InChIKey | AUHHYELHRWCWEZ-UHFFFAOYSA-N | | SMILES | Clc1c(Cl)c(Cl)c2C(=O)OC(=O)c2c1Cl | | LogP | 3.2 at 25℃ | | CAS DataBase Reference | 117-08-8(CAS DataBase Reference) | | NIST Chemistry Reference | 1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-(117-08-8) | | EPA Substance Registry System | Tetrachlorophthalic anhydride (117-08-8) |
| Hazard Codes | T,N,Xn | | Risk Statements | 45-41-42/43-50/53-48/22 | | Safety Statements | 53-22-24-26-37/39-45-60-61-36/37/39 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 2 | | RTECS | TI3450000 | | F | 10-21 | | TSCA | TSCA listed | | HazardClass | 9 | | PackingGroup | III | | HS Code | 29173990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Aquatic Acute 1
Aquatic Chronic 1
Carc. 1B
Eye Dam. 1
Resp. Sens. 1
Skin Sens. 1
STOT RE 2 | | Hazardous Substances Data | 117-08-8(Hazardous Substances Data) | | Toxicity | LD50 orally in Rabbit: > 15800 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
| | Tetrachlorophthalic anhydride Usage And Synthesis |
| Chemical Properties | white needle-like crystals or powder | | Uses | Intermediate in dyes, pharmaceuticals, plasticizers,
and other organic materials; flame-retardant
in epoxy resins. | | Uses | Tetrachlorophthalic Anhydride is used in the synthesis of nucleoside analogues with a specific structure as apoptosis inducing active compounds. Also used in the synthesis of carbonic anhydrase inhbitors. Chlorinated Reactive Flame Retardant Intermediate | | Definition | ChEBI: A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions. | | General Description | Odorless needle-like crystals or white powder. | | Air & Water Reactions | Sensitive to air and moisture. | | Reactivity Profile | 4,5,6,7-Tetrachloro-1,3-isobenzofurandione reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. | | Fire Hazard | Flash point data for 4,5,6,7-Tetrachloro-1,3-isobenzofurandione are not available. 4,5,6,7-Tetrachloro-1,3-isobenzofurandione is probably combustible. | | Flammability and Explosibility | Not classified | | Purification Methods | Crystallise the anhydride from chloroform or *benzene, then sublime it in a vacuum. [Beilstein 17/11 V 260.] |
| | Tetrachlorophthalic anhydride Preparation Products And Raw materials |
| Raw materials | Chlorine-->FUMING SULFURIC ACID-->Chlorosulfonic acid-->Phthalic anhydride-->Iodine-->o-Xylene | | Preparation Products | Acid Red 92-->Solvent Red 135-->Hexahydrophthalic anhydride-->CIS-1,2-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE-->N-METHYLTETRAFLUOROPHTHALIMIDE-->Tetrachlorophthalic acid-->Tetrachlorophthalimide-->2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN-->Solvent Red 135-->Acid Red 92-->Acid Red 94-->ROSE BENGAL LACTONE-->Solvent Yellow 157-->4,5,6,7-tetrachloro-2-(1,3-thiazol-2-yl)isoindole-1,3-dione-->3,4,5,6-tetrachloro-N-hexylphthalimide-->3,4,5,6-Tetrachlorophthalic acid bis(2-ethylhexyl) ester |
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