| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
PF 956980 manufacturers
- PF-00956980
-
- $1980.00
-
2026-07-27
- CAS:1262832-74-5
- Purity:
- Supply Ability: 10g
|
| | PF 956980 Basic information |
| Product Name: | PF 956980 | | Synonyms: | PF 956980;[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-pyrrolidin-1-ylmethanone;Methanone, [(3R,4R)-4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinyl-;PF-00956980 | | CAS: | 1262832-74-5 | | MF: | C18H26N6O | | MW: | 342.44 | | EINECS: | | | Product Categories: | | | Mol File: | 1262832-74-5.mol |  |
| | PF 956980 Chemical Properties |
| solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Pale Yellow | | Stability: | Hygroscopic |
| | PF 956980 Usage And Synthesis |
| Uses | PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. PF-956980 is used as immunosuppressive agent. | | Definition | ChEBI: PF-956980 is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a methyl[(3R,4R)-4-methyl-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]nitrilo group. It is a potent JAK3-selective chemical probe. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a pyrrolopyrimidine, a tertiary amino compound, a N-acylpiperidine and a N-acylpyrrolidine. | | in vivo | The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog
| Spesies | Dose (mg/kg) | Cl (mL/min/Kg) | Clunbound (mL/min/Kg) | Vss (L/Kg) | Terminal T1/2 (h) | Oral Bioavailability | |
| Rat i.v. | 0.5 | 48 | >48,000 | 0.8 | 2.1 | - | |
| Rat p.o. | 1 | - | - | - | - | <5% | |
| Dog i.v. | 0.1 | 18 | >18,000 | 1.0 | 2.0 | - | |
|
| | IC 50 | JAK1: 2.2 μM (IC50); JAK2: 23.1 μM (IC50); JAK3: 59.9 μM (IC50) |
| | PF 956980 Preparation Products And Raw materials |
|