- SKL2001
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- $34.00
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2026-06-02
- CAS:909089-13-0
- Purity: 99.99%
- Supply Ability: 10g
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| | SKL 2001 Basic information |
| Product Name: | SKL 2001 | | Synonyms: | CS-2771;SKL2001;SKL-2001;SKL 2001;SKL-2001;SKL 2001;SKL 2001;N-(3-(1H-imidazol-1-yl)propyl)-5-(furan-2-yl)isoxazole-3-carboxamide;5-(furan-2-yl)-N-[3-(1H-imidazol-1-yl)propyl]-1,2-oxazole-3-carboxamide;SKL2001 free base;Inhibitor,SKL-2001,Wnt,Beta catenin,SKL2001,SKL 2001,β-catenin,inhibit | | CAS: | 909089-13-0 | | MF: | C14H14N4O3 | | MW: | 286.29 | | EINECS: | | | Product Categories: | | | Mol File: | 909089-13-0.mol |  |
| | SKL 2001 Chemical Properties |
| Boiling point | 595.7±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 13.36±0.46(Predicted) | | color | White to off-white | | InChI | InChI=1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19) | | InChIKey | PQXINDBPUDNMPE-UHFFFAOYSA-N | | SMILES | O1C(C2=CC=CO2)=CC(C(NCCCN2C=NC=C2)=O)=N1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | SKL 2001 Usage And Synthesis |
| Description | SKL2001 is an activator of Wnt/β-catenin signaling. It increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner, increases β-catenin protein levels in HEK293 cells when used at concentrations of 10 and 30 μM, and disrupts the interaction between Axin and β-catenin. SKL2001 increases alkaline phosphatase (ALP) activity and mineralization in multipotent mesenchymal ST2 cells in a concentration-dependent manner, indicating increased osteoblastogenesis. SKL2001 (40 μM) reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells. It induces cell cycle arrest at the G0/G1 phase and increases E-cadherin and β-catenin protein levels in HCT116 cells when used at a concentration of 40 μM. | | Uses | SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1]. | | References | [1] Gwak J, et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. ell Res. 2012 Jan;22(1):237-47. DOI:10.1038/cr.2011.127
[2] Ohashi W, et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun. 2017 Nov 25;493(3):1342-1348. DOI:10.1016/j.bbrc.2017.09.161 |
| | SKL 2001 Preparation Products And Raw materials |
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