|
|
| | Mal-PEG4-Glu(OH)-NH-m-PEG24 Basic information |
| Product Name: | Mal-PEG4-Glu(OH)-NH-m-PEG24 | | Synonyms: | Mal-PEG4-Glu(OH)-NH-m-PEG24;MAL-dPEG??-Glu(OH)-NH-m-dPEG???;9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75,78-Tetracosaoxa-6-azanonaheptacontanoic acid, 4-[[19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1,17-dioxo-4,7,10,13-tetraoxa-16-azanonadec-1-yl]amino]-5-oxo-, (4S)- | | CAS: | 2204309-09-9 | | MF: | C72H134N4O35 | | MW: | 1615.84 | | EINECS: | | | Product Categories: | | | Mol File: | 2204309-09-9.mol |  |
| | Mal-PEG4-Glu(OH)-NH-m-PEG24 Chemical Properties |
| Boiling point | 1281.4±65.0 °C(Predicted) | | density | 1.167±0.06 g/cm3(Predicted) | | pka | 4.46±0.10(Predicted) |
| | Mal-PEG4-Glu(OH)-NH-m-PEG24 Usage And Synthesis |
| Uses | Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Mal-PEG4-Glu(OH)-NH-m-PEG24 Preparation Products And Raw materials |
|