ASP5878 manufacturers
- ASP5878
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- $60.00
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2026-07-27
- CAS:1453208-66-6
- Purity: 99.89%
- Supply Ability: 10g
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| | ASP5878 Basic information |
| Product Name: | ASP5878 | | Synonyms: | ASP5878;ASP-5878
(ASP5878;ASP5878; ASP 5878; ASP-5878;ASP 5878,Inhibitor,FGFR,ASP5878,Fibroblast growth factor receptor,inhibit;1H-Pyrazole-1-ethanol, 4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]-2-pyrimidinyl]amino]-;2-(4-((5-((2,6-Difluoro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)ethan-1-ol;ASP5878, 10 mM in DMSO | | CAS: | 1453208-66-6 | | MF: | C18H19F2N5O4 | | MW: | 407.37 | | EINECS: | | | Product Categories: | | | Mol File: | 1453208-66-6.mol |  |
| | ASP5878 Chemical Properties |
| Boiling point | 645.3±65.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 250 mg/mL (613.69 mM);Water : < 0.1 mg/mL (insoluble) | | pka | 14.41±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | ASP5878 Usage And Synthesis |
| Uses | ASP5878 is a selective inhibitor of FGFR1, 2, 3 and 4. | | in vivo | ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft and HCC orthotopic xenograft mouse model[1].
ASP5878 induces shrinkage of FGF19-expressing HCC xenograft model[1]. | Animal Model: | Four-week-old male nude mice (CAnN.Cg-Foxn1nu/CrlCrlj [nu/nu]) (Hep3B2.1-7 cells inoculated subcutaneously)[1]. | | Dosage: | 3 mg/kg. | | Administration: | Orally once daily from days 14 to 52. | | Result: | Induced tumor regression by 9% and 88% at 1 and 3 mg/kg, respectively, without affecting the body weight for 14 days.
Induced the suppression of FGFR4 phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation. |
| Animal Model: | HCC orthotopic xenograft model (mouse)[1]. | | Dosage: | 3 mg/kg. | | Administration: | Orally once daily for 24 days. | | Result: | Exhibited a lower tumor burden than vehicle- and sorafenibtreated mice.
Induced sustained tumor regression without tumor regrowth.
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| | IC 50 | FGFR1: 0.47 nM (IC50); FGFR2: 0.6 nM (IC50); FGFR3: 0.74 nM (IC50); FGFR4: 3.5 nM (IC50) |
| | ASP5878 Preparation Products And Raw materials |
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