607736-84-5
| 中文名称 | 607736-84-5 |
|---|---|
| 中文同义词 | 化合物 T13040;化合物 SUN 1334H |
| 英文名称 | SUN 1334H |
| 英文同义词 | SUN 1334H;2-?[[(2E)?-?4-?[4-?[bis(4-?Fluorophenyl)?methyl]?-?1-?piperazinyl]?-?2-?buten-?1-?yl]?oxy]?-acetic acid hydrochloride |
| CAS号 | 607736-84-5 |
| 分子式 | C23H27ClF2N2O3 |
| 分子量 | 452.93 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 607736-84-5.mol |
| 结构式 |  |
607736-84-5 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
Ki: 9.7 nM (H1 receptor)
SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC 50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K + -currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.
SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-U00084 | 607736-84-5 SUN 1334H | 607736-84-5 | 1mg | 1000元 |