- N-Boc-N'-Cbz-L-lysine
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- $999.00/ kg
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2025-07-28
- CAS:2389-45-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
- N-Boc-N'-Cbz-L-lysine
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- $2.00 / 100kg
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2025-06-25
- CAS:2389-45-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- N-Boc-N'-Cbz-L-lysine
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- $0.00 / 25kg
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2024-06-13
- CAS:2389-45-9
- Min. Order: 1kg
- Purity: 97%
- Supply Ability: 2T/month
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| | N-Boc-N'-Cbz-L-lysine Basic information |
| | N-Boc-N'-Cbz-L-lysine Chemical Properties |
| Melting point | 75.0 to 79.0 °C | | Boiling point | 587.0±50.0 °C(Predicted) | | density | 1.176±0.06 g/cm3(Predicted) | | refractive index | -8 ° (C=2.5, AcOH) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | almost transparency in Acetic acid | | pka | 3.99±0.21(Predicted) | | form | powder to crystal | | color | White to Almost white | | BRN | 1917222 | | InChIKey | BDHUTRNYBGWPBL-HNNXBMFYSA-N | | SMILES | C(O)(=O)[C@H](CCCCNC(OCC1=CC=CC=C1)=O)NC(OC(C)(C)C)=O | | CAS DataBase Reference | 2389-45-9(CAS DataBase Reference) | | EPA Substance Registry System | N2-tert-Butoxycarbonyl-N6-benzyloxycarbonyl lysine (2389-45-9) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 2924 29 70 |
| | N-Boc-N'-Cbz-L-lysine Usage And Synthesis |
| Uses | Boc-Lys(Z)-OH, is used in the synthesis of Isodesmosine Chloride (I815050), which is a component of elastin. | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | The general procedure for the synthesis of N-Boc-N'-Cbz-L-lysine from N-alpha-Boc-L-lysine and phenylmethoxycarbonylsuccinimide was as follows: to a mixed solution of (2S)-6-amino-2-(tert-butoxycarbonylamino)hexanoic acid (100.00 g, 406.01 mmol, 1.00 equiv) and NaHCO3 (102.33 g 1.22 mol, 3.00 eq.) in a mixed solution of THF (1000 mL) and water (1000 mL) was slowly added CbzOSu (101.19 g, 406.01 mmol, 1.00 eq.) at 0 °C. Subsequently, the reaction mixture was stirred at 30 °C for 16 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 5-6 with 1N HCl and then extracted with ethyl acetate (600 mL x 3). The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to afford the target product (2S)-6-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)hexanoic acid (142.00 g, 373.26 mmol, 91.9% yield) as a yellow oil. | | References | [1] Patent: US2016/96830, 2016, A1. Location in patent: Paragraph 0368-0369 |
| | N-Boc-N'-Cbz-L-lysine Preparation Products And Raw materials |
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