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| | HC≡C-CH2-PEG8-SH Basic information |
| Product Name: | HC≡C-CH2-PEG8-SH | | Synonyms: | HC≡C-CH2-PEG8-SH;Propargyl-PEG8-SH;HS-PEG8-Propyne;3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yne-1-thiol | | CAS: | 1422540-92-8 | | MF: | C19H36O8S | | MW: | 424.55 | | EINECS: | | | Product Categories: | | | Mol File: | 1422540-92-8.mol |  |
| | HC≡C-CH2-PEG8-SH Chemical Properties |
| Boiling point | 490.3±45.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | pka | 9+-.0.10(Predicted) |
| | HC≡C-CH2-PEG8-SH Usage And Synthesis |
| Uses | Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG8-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | Biological Activity | Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HC≡C-CH2-PEG8-SH Preparation Products And Raw materials |
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