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GSK9311 manufacturers
- GSK9311
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- $108.00
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2026-04-22
- CAS:1923851-49-3
- Purity:
- Supply Ability: 10g
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| | GSK9311 Basic information |
| Product Name: | GSK9311 | | Synonyms: | GSK9311;GSK 9311;GSK-9311;BRPF1 bromodomain inhibitor GS9311;GSK 9311 hydrochloride;Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxy-;GSK9311 >=98% (HPLC) | | CAS: | 1923851-49-3 | | MF: | C24H31N5O3 | | MW: | 437.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1923851-49-3.mol |  |
| | GSK9311 Chemical Properties |
| Boiling point | 625.5±55.0 °C(Predicted) | | density | 1.204±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 30 mg/mL (68.57 mM) | | pka | 8.82±0.40(Predicted) | | form | Solid | | color | White to off-white | | Optical Rotation | [α]/D 90 to 100°, c =0.3 in methanol | | InChIKey | WFXIHQFRQPGCCR-MRXNPFEDSA-N | | SMILES | O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(N(CC)C(C4=C(OC)C=CC=C4)=O)C=C2N1C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | GSK9311 Usage And Synthesis |
| Uses | GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1]. | | Biological Activity | GSK9311 is a negative control for the SGC epigenetic probe GSK6853. GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells), and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probe, GSK6853, please visit the GSK6853 probe summary on the Structural Genomics Consortium (SGC) website.
GSK6853, the active probe, is available from Sigma. To learn more about and purchase GSK6853, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc | | IC 50 | BRPF1: 6.0 (pIC50); BRPF2: 4.3 (pIC50) | | References | [1] Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7. DOI:10.1021/acsmedchemlett.6b00092 |
| | GSK9311 Preparation Products And Raw materials |
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