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Product Name:THK5351
CAS:1707147-26-9
Remarks:THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain. THK5351 bound to AD hippocampal homogenates with high affinity (Kd = 2.9 nmol/L; Bmax = 368.3 p
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THK5351 manufacturers
- THK5351
-
- $147.00
-
2026-04-23
- CAS:1707147-26-9
- Purity: 99.33%
- Supply Ability: 10g
- THK5351
-
- $147.00
-
2026-04-23
- CAS:1707147-26-9
- Purity: 99.33%
- Supply Ability: 10g
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| | THK5351 Basic information |
| Product Name: | THK5351 | | Synonyms: | THK5351;THK5351?, >98%，>98%ee;2-Propanol, 1-fluoro-3-[[2-[6-(methylamino)-3-pyridinyl]-6-quinolinyl]oxy]-, (2S)-;THK5351, 10 mM in DMSO;(S)-1-Fluoro-3-((2-(6-(methylamino)pyridin-3-yl)quinolin-6-yl)oxy)propan-2-ol | | CAS: | 1707147-26-9 | | MF: | C18H18FN3O2 | | MW: | 327.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1707147-26-9.mol |  |
| | THK5351 Chemical Properties |
| Boiling point | 561.5±50.0 °C(Predicted) | | density | 1.283±0.06 g/cm3(Predicted) | | pka | 12.82±0.20(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | THK5351 Usage And Synthesis |
| Uses | THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain. | | in vivo | THK5351 exhibits favorable pharmacokinetics and no defluorination in mice. 18F-THK5351 enters the brain immediately after intravenous injection and shows a fast washout from the brain. At 0.1 and 1 mg/kg, no animals died and no treatment-related changes in any animal are noted in clinical observations, body weight measurement, and pathologic examination[1]. Autoradiography in the brain sections of patients with PSP demonstrates [3H]THK-5351 binding to tau deposits with a high selectivity. Although patients with PSP exhibits no remarkable [18F]THK-5351 retention in the temporal cortex, significantly higher tracer retention is observed in the globus pallidus and midbrain[2]. | | References | [1] Harada R, et al. 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J Nucl Med. 2016 Feb;57(2):208-14. DOI:10.2967/jnumed.115.164848
[2] Ishiki A, et al. Tau imaging with [18 F]THK-5351 in progressive supranuclear palsy. Eur J Neurol. 2017 Jan;24(1):130-136. DOI:10.1111/ene.13164 |
| | THK5351 Preparation Products And Raw materials |
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