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3'-Azido-3'-deoxy-5-methylcytidine manufacturers
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| | 3'-Azido-3'-deoxy-5-methylcytidine Basic information |
| Product Name: | 3'-Azido-3'-deoxy-5-methylcytidine | | Synonyms: | 3'-Azido-3'-deoxy-5-methylcytidine;3'-Azido-3'-deoxy-5-methylcytidin;HIV,Inhibitor,inhibit,Human immunodeficiency virus,3'Azido3'deoxy5methylcytidine,Reverse Transcriptase,3' Azido 3' deoxy 5 methylcytidine;3''-Azido-3''-deoxy-5-methylcytidine, 10 mM in DMSO | | CAS: | 1282040-14-5 | | MF: | C10H14N6O4 | | MW: | 282.26 | | EINECS: | | | Product Categories: | | | Mol File: | 1282040-14-5.mol |  |
| | 3'-Azido-3'-deoxy-5-methylcytidine Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic) | | form | Solid | | color | Light yellow to yellow |
| | 3'-Azido-3'-deoxy-5-methylcytidine Usage And Synthesis |
| Uses | 3'-Azido-3'-deoxy-5-methylcytidine (CS-92) is a potent xenotropic murine leukemia-related retrovirus (XMRV) inhibitor with a CC50 of 43.5 μM in MCF-7 cells. 3'-Azido-3'-deoxy-5-methylcytidine also inhibits HIV-1 reverse transcriptase with an EC50 of 0.06 μM in peripheral blood mononuclear (PBM) cells[1]. 3'-Azido-3'-deoxy-5-methylcytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | HIV-1: 0.06 μM (EC50, in PBM cells); XMRV: 43.5 μM (CC50, in MCF-7 cells) | | References | [1] Singh IR, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PLoS One. 2010 Apr 1;5(4):e9948. DOI:10.1371/journal.pone.0009948 |
| | 3'-Azido-3'-deoxy-5-methylcytidine Preparation Products And Raw materials |
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