175212-04-1
| 中文名称 | 175212-04-1 |
|---|---|
| 中文同义词 | 化合物 T14986;CMI977 (LDP977) |
| 英文名称 | CMI977 |
| 英文同义词 | CMI977;LDP977;Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy-;1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea;CMI977 (LDP977) |
| CAS号 | 175212-04-1 |
| 分子式 | C16H19FN2O4 |
| 分子量 | 322.33 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 175212-04-1.mol |
| 结构式 |  |
175212-04-1 性质
| 熔点 | 106-107 °C |
|---|---|
| 沸点 | 524.8±60.0 °C(Predicted) |
| 密度 | 1.33±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 10.12±0.50(Predicted) |
CMI977 是一种有效的 5-Lipoxygenase (5-LO) 抑制剂。
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5-LO
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CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.