FR-188582

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CAS:189699-82-9
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FR-188582 Basic information
Product Name:FR-188582
Synonyms:FR-188582;1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-;FR 188582,FR188582
CAS:189699-82-9
MF:C16H13ClN2O2S
MW:332.8
EINECS:
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Mol File:189699-82-9.mol
FR-188582 Structure
FR-188582 Chemical Properties
Boiling point 539.7±50.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka-3.80±0.10(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
FR-188582 Usage And Synthesis
UsesFR-188582 is a highly selective inhibitor of cyclooxygenase (COX)-2, with an IC50 value of 17 nM.
in vivo

Oral administration of FR-188582 (0.01-3.2 mg/kg) reverses paw edema in adjuvant arthritic rats and shows a therapeutic effect in a dose-dependent manner with ED50 values (95% C.L.) of 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively. The anti-inflammatory effect of FR-188582 (FR188582) is threefold more potent than that of Indomethacin with ED50 values (95% C.L.) of 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively[1].

IC 50COX-2: 17 nM (IC50)
References[1] Ochi T, et al. The anti-inflammatory effect of FR188582, a highly selective inhibitor of cyclooxygenase-2, with an ulcerogenic sparing effect in rats. Jpn J Pharmacol. 2001 Feb;85(2):175-82. DOI:10.1254/jjp.85.175
FR-188582 Preparation Products And Raw materials
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