T-3364366 manufacturers
- T-3364366
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- $33.00 / 2mg
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2026-03-13
- CAS:1356354-09-0
- Min. Order:
- Purity: 99.90%
- Supply Ability: 10g
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| | T-3364366 Basic information |
| Product Name: | T-3364366 | | Synonyms: | T-3364366;N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide;N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3H,4H-thieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide;Acetamide, N-[2-[[3,4-dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]-;T-3364366, 10 mM in DMSO | | CAS: | 1356354-09-0 | | MF: | C18H16F3N3O3S2 | | MW: | 443.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1356354-09-0.mol |  |
| | T-3364366 Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 15.66±0.46(Predicted) | | color | White to off-white |
| | T-3364366 Usage And Synthesis |
| Uses | T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1]. | | storage | Store at +4°C | | References | [1] Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72. DOI:10.1021/acsmedchemlett.6b00241 |
| | T-3364366 Preparation Products And Raw materials |
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