化合物 T16709
| 中文名称 | 化合物 T16709 |
|---|---|
| 中文同义词 | 二酰基甘油激酶5/DGK-Ε抗体;化合物 T16709;R 59-022,二酰基甘油激酶抑制剂;二酰基甘油激酶抑制剂;化合物 R 59-022;6-(2-(4-((4-氟苯基)(苯基)亚甲基)哌啶-1-基)乙基)-7-甲基-5H-噻唑并[3,2-A]嘧啶-5-酮;二乙酰基甘油激酶;甘油二酯激酶 |
| 英文名称 | DIACYLGLYCEROL KINASE INHIBITOR I |
| 英文同义词 | 6-[2-[4-[(P-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO(3,2-A)PYRIMIDINE-5-ONE;6-[2-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL)ETHYL]-7-METHYL-5H-THIAZOLO-[3,2-A]-PYRIMIDIN-5-ONE;6-[2-[4-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE;DIACYLGLYCEROL KINASE;DIACYLGLYCEROL KINASE INHIBITOR I;DIACYLGLYCEROL KINASE INHIBITOR I (R59 022);DAGK;DAG KINASE |
| CAS号 | 93076-89-2 |
| 分子式 | C27H26FN3OS |
| 分子量 | 459.58 |
| EINECS号 | |
| 相关类别 | Lipid signaling |
| Mol文件 | 93076-89-2.mol |
| 结构式 |  |
化合物 T16709 性质
| 沸点 | 619.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 0.1 M HCl：微溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.76±0.20(Predicted) |
| 颜色 | 淡黄色低 |
| 生物来源 | synthetic (organic) |
| 稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
| InChI | 1S/C27H26FN3OS/c1-19-24(26(32)31-17-18-33-27(31)29-19)13-16-30-14-11-22(12-15-30)25(20-5-3-2-4-6-20)21-7-9-23(28)10-8-21/h2-10,17-18H,11-16H2,1H3 |
| InChIKey | MFVJXLPANKSLLD-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)C(=C3CCN(CC3)CCc4[c]([n]5c([s]cc5)nc4C)=O)c2ccccc2 |
|
PKC
|
serotonin
|
diacylglycerol kinase 2.8 μM (IC 50 ) |
In the intact platelet, R 59-022 is able to interrupts thrombin-induced inositol lipid cycling at the level of diacylglycerol and leads to an elevation of protein kinase C activity.
R 59-022 (10 μM) potentiates aggregation, but not shape change induced by sub-maximal concentrations of thrombin. R59022 (10 μM) had no significant effect on the dose-response curve for the mobilization of intracellular Ca
2+
by thrombin in either the presence or the absence of extracellular Ca
2+
.
R 59-022, an inhibitor of filovirus entry, prevents the macropinocytic uptake of filoviral particles, inhibits entry mediated by multiple filovirus GPs, and blocks replicative EBOV growth. R 59-022 blocks entry of EBOV pseudotypes in a concentration-dependent manner (IC
50
: ~5 µM). R 59-022 dose-dependent decreases in entry by the VLPs harboring the EBOV GP (IC
50
: ~2 µM). R 59-022 (2-12 μM; 1 hour) can inhibit EBOV GP-mediated entry in multiple cell types. R 59-022 (5 µM; 30 minutes) blocks macropinocytosis in vero cells.
安全信息
| 安全说明 | 23-24/25 |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-107613 | 化合物 T16709 R 59-022 | 93076-89-2 | 5mg | 1850元 |
| 2025/12/22 | HY-107613 | 化合物 T16709 R 59-022 | 93076-89-2 | 10mM * 1mLin DMSO | 1870元 |