1363281-27-9
| 中文名称 | 1363281-27-9 |
|---|---|
| 中文同义词 | (4-氟苯基)(2-(苯氧基甲基)-6,7-二氢恶唑并[5,4-C]吡啶-5(4H)-基)甲酮;化合物 T15619;化合物 JNJ-46778212;化合物 T15619,10 MM DMSO 溶液 |
| 英文名称 | VU 0409551 |
| 英文同义词 | VU 0409551;JNJ-46778212;[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone;(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone;Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-;JNJ 46778212,JNJ46778212;(4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone;JNJ-46778212, 10 mM in DMSO |
| CAS号 | 1363281-27-9 |
| 分子式 | C20H17FN2O3 |
| 分子量 | 352.36 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1363281-27-9.mol |
| 结构式 |  |
1363281-27-9 性质
| 沸点 | 545.8±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.308±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：可溶；乙醇：可溶 |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 1.35±0.20(Predicted) |
| 颜色 | 浅黄至黄色 |
| InChIKey | QUZLMKNNIUSREV-UHFFFAOYSA-N |
| SMILES | O=C(N1CCC2=C(C1)OC(COC3=CC=CC=C3)=N2)C4=CC=C(C=C4)F |
JNJ-46778212 (VU 0409551) 是 mGlu5 正变构调节剂，EC50 值为260 nM。
|
mGlu5 Receptor 260 nM (EC 50 ) |
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR −/− mice. The administration of JNJ-46778212 to SR −/− mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-19559 | 1363281-27-9 JNJ-46778212 | 1363281-27-9 | 5 mg | 700元 |
| 2026/06/05 | HY-19559 | 1363281-27-9 JNJ-46778212 | 1363281-27-9 | 10mM * 1mLin DMSO | 770元 |