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| | Benzoic acid, 4-[3-[(4-methylphenyl)sulfonyl]-2-[[(4-methylphenyl)sulfonyl]methyl]-1-oxopropyl]- Basic information |
| | Benzoic acid, 4-[3-[(4-methylphenyl)sulfonyl]-2-[[(4-methylphenyl)sulfonyl]methyl]-1-oxopropyl]- Chemical Properties |
| Boiling point | 803.7±65.0 °C(Predicted) | | density | 1.346±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | Solid | | pka | 3.70±0.10(Predicted) | | Appearance | White to off-white Solid |
| | Benzoic acid, 4-[3-[(4-methylphenyl)sulfonyl]-2-[[(4-methylphenyl)sulfonyl]methyl]-1-oxopropyl]- Usage And Synthesis |
| Uses | 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid (Bis-sulfone Acid) is a strong covalent linker featuring a free carboxylic acid and two tosyl groups. Each tosyl group can be displaced by thiol or amine nucleophiles via a Michael addition, and the inclusion of two on this molecule allow this reaction to proceed twice. This may be used to “staple” two reduced cysteine residues on a given protein to reform disulfide bridges. The carboxylic acid is free to react to form amides or esters. |
| | Benzoic acid, 4-[3-[(4-methylphenyl)sulfonyl]-2-[[(4-methylphenyl)sulfonyl]methyl]-1-oxopropyl]- Preparation Products And Raw materials |
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