Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid manufacturers
- Cyclo(-RGDfK) TFA
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- $47.00 / 1mg
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2025-07-25
- CAS:500577-51-5
- Min. Order:
- Purity: 99.54%
- Supply Ability: 10g
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| | Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Basic information |
| Product Name: | Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid | | Synonyms: | Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid;Cyclo(-RGDfK) Trifluoroacetate;2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Trifluoroacetate (1:1);Cyclo(-RGDfK) TFA, 10 mM in DMSO;Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate | | CAS: | 500577-51-5 | | MF: | C29H42F3N9O9 | | MW: | 717.6938896 | | EINECS: | | | Product Categories: | | | Mol File: | 500577-51-5.mol |  |
| | Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO: 100 mg/mL (139.34 mM) | | form | Solid | | color | White to off-white | | Water Solubility | Water: 33.33 mg/mL (46.44 mM) | | Sequence | Cyclo(Arg-Gly-Asp-Phe-Lys) |
| | Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Usage And Synthesis |
| Uses | Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3]. | | IC 50 | αvβ3: 0.94 nM (IC50) | | References | [1] Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. DOI:10.1021/mp5000746
[2] Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. DOI:10.1016/j.nucmedbio.2014.09.010 |
| | Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Preparation Products And Raw materials |
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