3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine

3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine Suppliers list

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:GSK-843 CAS:1601496-05-2 Purity:99.18% Package:1mg;149USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	Career Henan Chemica Co
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Products Intro:	Product Name:3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine CAS:1601496-05-2 Purity:0.99 Package:1KG;7KG Judy@corechem.com

Company Name:	TargetMol Chemicals Inc.
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Products Intro:	Product Name:GSK-843 CAS:1601496-05-2 Purity:99.18% Package:1mg;149USD

Company Name:	Wuhan Topule Biopharmaceutical Co., Ltd
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Products Intro:	Product Name:GSK-843 CAS:1601496-05-2 Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

Company Name:	Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Products Intro:	Product Name:GSK-843 CAS:1601496-05-2 Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services

3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine manufacturers

3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine Basic information

Product Name:	3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
Synonyms:	3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine;GSK-843;Thieno[3,2-c]pyridin-4-amine, 3-(5-benzothiazolyl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)-;GSK843,GSK 843;GSK'843;3-(Benzo[d]thiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine;GSK-843, 10 mM in DMSO
CAS:	1601496-05-2
MF:	C19H15N5S2
MW:	377.49
EINECS:
Product Categories:
Mol File:	1601496-05-2.mol

3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine Chemical Properties

Safety Information

MSDS Information

3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine Usage And Synthesis

Uses	GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation[1][2].
Biological Activity	GSKμ843 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 6.5 nM) with much reduced or little affinity toward 262 other kinases (IC50 >1 μM against 10 μM ATP in competitive binding assay), including RIP5. GSKμ843 effectively suppresses TNF/Z-VAD-FMK/IAP agonist treatment-induced necrosis induction in both human and murine cell cultures (EC50 ranges from <0.12 to 3 μM), while inducing apoptosis in the absence of caspase inhibitor as a result of caspase 8 activation via RHIM-driven recruitment to assemble a Casp8-FADD-cFLIP complex independent of pronecrotic kinase activities and MLKL.
IC 50	RIPK3
References	[1] Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95. DOI:10.1016/j.molcel.2014.10.021 [2] Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288(43):31268-79. DOI:10.1074/jbc.M113.462341

3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine Preparation Products And Raw materials

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