- 1-(Bromomthy)Naphthalene
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- $15.00 / 1KG
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2021-07-13
- CAS:3163-27-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 1-(Bromomthy)Naphthalene
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- $15.00 / 1KG
-
2021-07-09
- CAS:3163-27-7
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 1-(Bromomethyl)naphthalene Basic information |
| Product Name: | 1-(Bromomethyl)naphthalene | | Synonyms: | Naphthalene, 1-(bromomethyl)-;1-BROMOMETHYL NAPHTHALENE;1-BROMOMETHYL NAPHTHALENE 99.73%;1-(Bromomthy)Naphthalene;1-(Bromomethy)naphthalene;(1-Naphtyl)bromomethane;1-Naphtylmethyl bromide;1-(Bromomethyl)napht | | CAS: | 3163-27-7 | | MF: | C11H9Br | | MW: | 221.09 | | EINECS: | 801-817-2 | | Product Categories: | Naphthalene series | | Mol File: | 3163-27-7.mol |  |
| | 1-(Bromomethyl)naphthalene Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36 | | RIDADR | 3261 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29036990 |
| | 1-(Bromomethyl)naphthalene Usage And Synthesis |
| Chemical Properties | Off-white powder | | Uses | It is employed as a intermediate for organic synthesis and pharmaceutical. | | Synthesis | The general procedure for the synthesis of 1-bromomethylnaphthalene from 1-naphthalenemethanol: Ethyl α,α-diacetoacetate (0.41 mmol, 1.2 eq.), 1-naphthalenemethanol (0.34 mmol, 1.0 eq.), and triphenylphosphine (0.68 mmol, 2.0 eq.) were added to 3 mL of dichloroethane (DCE) at room temperature and the reaction took place in air. The progress of the reaction was monitored by thin layer chromatography (TLC) during the reaction. Upon completion of the reaction, the reaction was quenched by the addition of 3 mL of water, followed by extraction with ethyl acetate (3 x 3 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography, and the eluent was petroleum ether or a mixed solvent of petroleum ether and ethyl acetate, and the target product 1-bromomethyl naphthalene was finally obtained. | | References | [1] Synthetic Communications, 2010, vol. 40, # 11, p. 1646 - 1649
[2] Organic Letters, 2003, vol. 5, # 8, p. 1167 - 1169
[3] Tetrahedron Letters, 2014, vol. 55, # 1, p. 90 - 93
[4] Canadian Journal of Chemistry, 1981, vol. 59, p. 2629 - 2641
[5] Tetrahedron, 2003, vol. 59, # 52, p. 10453 - 10463 |
| | 1-(Bromomethyl)naphthalene Preparation Products And Raw materials |
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