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| | QGOICCMBEDDFCI-NXQGQTBASA-N Basic information |
| Product Name: | QGOICCMBEDDFCI-NXQGQTBASA-N | | Synonyms: | QGOICCMBEDDFCI-NXQGQTBASA-N;AM-7209;Benzoic acid, 4-[[2-[(3R,5R,6S)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[(1,1-dimethylethyl)sulfonyl]ethyl]-3-methyl-2-oxo-3-piperidinyl]acetyl]amino]-2-methoxy-;AMG 7209;AMG7209;AMG-7209 | | CAS: | 1623432-51-8 | | MF: | C37H41Cl2FN2O7S | | MW: | 747.7 | | EINECS: | | | Product Categories: | | | Mol File: | 1623432-51-8.mol |  |
| | QGOICCMBEDDFCI-NXQGQTBASA-N Chemical Properties |
| | QGOICCMBEDDFCI-NXQGQTBASA-N Usage And Synthesis |
| Description | AMG-7209 is a potent and selective inhibitor of the MDM2-p53 interaction. | | Uses | AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities[1]. | | References | [1] Yosup Rew, et al. Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem. 2014 Dec 26;57(24):10499-511. DOI:10.1021/jm501550p |
| | QGOICCMBEDDFCI-NXQGQTBASA-N Preparation Products And Raw materials |
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