- DL-Dithiothreitol
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- $5.00 / 1kg
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2026-05-09
- CAS:27565-41-9
- Min. Order: 0.001kg
- Purity: 99%
- Supply Ability: 10000kg
- D-1,4-dithiothreitol
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- $2.20 / 100KG
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2026-04-17
- CAS:27565-41-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons
- DL-Dithiothreitol
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- $30.00 / 1KG
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2025-06-27
- CAS:27565-41-9
- Min. Order: 50KG
- Purity: 99%
- Supply Ability: 500000kg
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| | DL-Dithiothreitol Basic information |
| | DL-Dithiothreitol Chemical Properties |
| Melting point | 41-44 °C(lit.) | | Boiling point | 125-130 °C (2 mmHg) | | density | 1.04 g/mL at 20 °C | | refractive index | 1.5200 (estimate) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | H2O: 50 mg/mL, clear, colorless | | form | Liquid | | color | White | | Water Solubility | Soluble | | Merck | 3376 | | InChI | InChI=1/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/s3 | | InChIKey | VHJLVAABSRFDPM-APQYWOSTNA-N | | SMILES | [C@@H](O)(CS)[C@H](O)CS |&1:0,4,r| | | CAS DataBase Reference | 27565-41-9(CAS DataBase Reference) | | EPA Substance Registry System | 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-(27565-41-9) |
| Hazard Codes | Xn | | Risk Statements | 25-36/37/38-22 | | Safety Statements | 26-45-36 | | WGK Germany | 3 | | RTECS | EK1610000 | | F | 3-10-16-23 | | HS Code | 29309090 | | Toxicity | mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949. |
| | DL-Dithiothreitol Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins. | | Uses | DTT is a cell permeable protective agent for Thiol groups. | | Preparation | The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis. | | Definition | ChEBI: D-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a L-1,4-dithiothreitol. | | Purification Methods | Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.] |
| | DL-Dithiothreitol Preparation Products And Raw materials |
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