N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide

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N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide Basic information
Product Name:N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide
Synonyms:N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide;1H-Benzimidazole-5-sulfonamide, 2,3-dihydro-N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylthio)-1-naphthalenyl]-2-oxo-;hsa62
CAS:780822-35-7
MF:C19H14N6O4S2
MW:454.48
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Mol File:780822-35-7.mol
N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide Structure
N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide Chemical Properties
density 1.78±0.1 g/cm3(Predicted)
pka6.82±0.50(Predicted)
Safety Information
MSDS Information
N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide Usage And Synthesis
Useshsa62 is a dual inhibitor for SIRT1 and SIRT2, with IC50 of 1.3 and 5.5 μM, respectively[1].
IC 50SIRT1: 1.3 μM (IC50); SIRT2: 5.5 μM (IC50); SIRT3: 43.6 μM (IC50)
References[1] Cai H, et al., Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790. DOI:10.1021/acs.jcim.3c00556
N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide Preparation Products And Raw materials
Tag:N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide(780822-35-7) Related Product Information
Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) gamma-Glu-Cys trifluoroacetate salt Nicotinamide Nicotinamide riboside chloride N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Acetamide, 2-[(3,4-dihydro-4-oxo-2-quinazolinyl)thio]-N-[5-[(4-nitrophenyl)sulfonyl]-2-thiazolyl]-