U-75302 manufacturers
- U75302
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- $3450.00 / 1mg
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2026-01-05
- CAS:119477-85-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | U-75302 Basic information |
| Product Name: | U-75302 | | Synonyms: | 6-[6-(3-HYDROXY-1E,5Z-UNDECADIENYL)-2-PYRIDINYL]-1,5-HEXANEDIOL;6-(6-(3R-HYDROXY-1E,5Z-UNDECADIEN-1-YL)-2-PYRIDINYL)-1,5S-HEXANEDIOL;U-75302;(5R)-6-[6-[(1E,3S,5Z)-3-Hydroxy-1,5-undecadienyl]-2-pyridinyl]-1,5-hexanediol;(5R)-6-[6-[(3S,2E,5Z)-3-Hydroxy-1,5-undecadienyl]-2-pyridinyl]-1,5-hexanediol;1,5-Hexanediol, 6-[6-[(1E,3R,5Z)-3-hydroxy-1,5-undecadien-1-yl]-2-pyridinyl]-, (5S)- | | CAS: | 119477-85-9 | | MF: | C22H35NO3 | | MW: | 361.52 | | EINECS: | | | Product Categories: | | | Mol File: | 119477-85-9.mol |  |
| | U-75302 Chemical Properties |
| storage temp. | −20°C | | solubility | DMSO: 10 mg/mL | | form | oil | | color | light yellow |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | U-75302 Usage And Synthesis |
| Description | U-75302 is an LTB4 receptor antagonist with a Ki of 159 nM on guinea pig lung membranes. This activity is specific for the BLT1 receptor; U-75302 does not antagonize the binding of [3H]-LTB4 to the human BLT2 receptor. | | Uses | U-75302 is a selective leukotriene B4 antagonist. | | References | [1] R C FALCONE D A. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents.[J]. Journal of Pharmacology and Experimental Therapeutics, 1990, 255 2: 565-571.
[2] ALICE H. LIN. Novel Molecules That Antagonize Leukotriene B4 Binding to Neutrophils[J]. Annals of the New York Academy of Sciences, 1988, 524 1: 196-200. DOI: 10.1111/j.1749-6632.1988.tb38542.x [3] S WANG. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.[J]. The Journal of Biological Chemistry, 2000, 275 52: 40686-40694. DOI: 10.1074/jbc.m004512200 [4] SHIGEYASU TSUDA. Novel Mechanism of Regulation of the 5-lipoxygenase/leukotriene B4 Pathway by High-Density Lipoprotein in Macrophages[J]. Atherosclerosis. Supplements, 2018, 1 1. DOI: 10.1016/j.atherosclerosissup.2018.04.186 |
| | U-75302 Preparation Products And Raw materials |
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