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| | Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate Basic information |
| Product Name: | Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate | | Synonyms: | ETHYL 2-CHLORO-4-METHYLTHIAZOLE-5-CARBOXYLATE;Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate ,97%;Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate 97%;2-Chloro-4-methyl-5-thiazolecarboxylic acid ethyl ester;2-Chloro-4-methyl-5-ethoxycarbonylthiazole;2-Chloro-4-methylthiazole-5-carboxylic acid ethyl ester;5-Thiazolecarboxylic acid, 2-chloro-4-methyl-, ethyl ester;Ethyl 2-chloro-4-methyl-5-thiazolecarboxylate | | CAS: | 7238-62-2 | | MF: | C7H8ClNO2S | | MW: | 205.66 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 7238-62-2.mol |  |
| | Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate Chemical Properties |
| Melting point | 46 °C | | Boiling point | 116℃ | | density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. -20°C | | pka | -0.10±0.10(Predicted) | | Appearance | White to off-white Solid |
| Hazard Note | Harmful | | HS Code | 2934100090 |
| | Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate Usage And Synthesis |
| Definition | ChEBI: Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate is an aromatic carboxylic acid and a member of thiazoles. | | Synthesis | Intermediate Example L; Synthesis of ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate (X-1): ethyl 2-oxo-4-methyl-3H-thiazole-5-carboxylate (0.57 g, 3.05 mmol) was mixed with phosphorus triclosan (5 mL) and heated to react for 18 hours at 120°C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove excess phosphorous trichloride. Water (15 mL) was slowly added to the residue and stirred for 10 minutes. The aqueous phase was extracted with ether (3 x 15 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (ethyl acetate/hexane as eluent) to afford ethyl 2-chloro-4-methylthiazole-5-carboxylate as a white solid (0.54 g, 86% yield).1H NMR (400 MHz, CDCl3) δ 4.32 (q, J = 7.1 Hz, 2H), 2.68 (s, 3H), 1.35 (t, J = 7.1 Hz, 3H). 3H). | | References | [1] Journal of Heterocyclic Chemistry, 1985, vol. 22, p. 1621 - 1630
[2] Patent: WO2005/51890, 2005, A1. Location in patent: Page/Page column 67-68
[3] Proceedings - Indian Academy of Sciences, Section A, 1945, # 22, p. 362,376
[4] Patent: US5817829, 1998, A |
| | Ethyl 2-chloro-4-methyl-1,3-thiazole-5-carboxylate Preparation Products And Raw materials |
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