5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide

Request For Quotation
5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:LY5；LY-5;LY 5
CAS:1436382-03-4
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-0533-2185556 +8615965530500
Email: nickzhang@hangyubiotech.com
Products Intro: Product Name:LY5
CAS:1436382-03-4
Purity:99% Package:mg,g,kg
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:LY5
CAS:1436382-03-4
Purity:98 Package:500mg；1g；5g；10g；25g Remarks:Provide customized services
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:LY5
CAS:1436382-03-4
Package:50mg;954USD|100mg;1440USD|25mg;734USD
Company Name: Shanghai Topbiochem Technology Co., Ltd  
Tel: 021-58170097
Email: info@topbiochem.com
Products Intro: Product Name:5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide
CAS:1436382-03-4
Purity:95% Package:10g;100g;1kg

5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide manufacturers

  • LY5
  • LY5 pictures
  • $954.00
  • 2026-04-20
  • CAS:1436382-03-4
  • Purity:
  • Supply Ability: 10g
5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide Basic information
Product Name:5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide
Synonyms:5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide;1-Naphthalenesulfonamide, 5,8-dihydro-5,8-dioxo-6-(3-pyridinylamino)-;5,8-Dioxo-6-(pyridin-3-ylamino)-5,8-dihydro-naphthalene-1-sulfonicacidamide;5,8-dioxo-6-(pyridin-3-ylamino)-5,8-dihydronaphthalene-1-sulfonamide
CAS:1436382-03-4
MF:C15H11N3O4S
MW:329.33
EINECS:
Product Categories:
Mol File:1436382-03-4.mol
5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide Structure
5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide Chemical Properties
Boiling point 635.6±65.0 °C(Predicted)
density 1.585±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka9.15±0.20(Predicted)
Safety Information
MSDS Information
5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide Usage And Synthesis
DescriptionLY5 is a STAT3 inhibitor. It acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.
UsesLY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer[1].
in vivo

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo[1].

Animal Model:Nude mice with MDA-MB-231 cancer cells injection[1]
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:Suppressed tumor growth and significantly reduced the tumor sizes.
References[1] Yu W, et al. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. J Med Chem. 2013 Jun 13;56(11):4402-12. DOI:10.1021/jm400080c
5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide Preparation Products And Raw materials
Raw materials1-Naphthalenesulfonamide, 5,8-dihydro-5,8-dioxo--->1-Naphthalenesulfonyl chloride-->3-Aminopyridine
Tag:5,8-dioxo-6-(pyridin-3-ylamino)naphthalene-1-sulfonamide(1436382-03-4) Related Product Information