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| | 2-CHLORO-6-HYDRAZINOPYRIDINE Basic information |
| | 2-CHLORO-6-HYDRAZINOPYRIDINE Chemical Properties |
| Melting point | 118°C | | Boiling point | 118°C | | density | 1.43±0.1 g/cm3(Predicted) | | Fp | 117-120°C | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | pka | 9.08±0.70(Predicted) | | form | powder to crystal | | color | Light yellow to Brown | | InChI | InChI=1S/C5H6ClN3/c6-4-2-1-3-5(8-4)9-7/h1-3H,7H2,(H,8,9) | | InChIKey | HFTSPKIAXHZROA-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC(NN)=CC=C1 | | CAS DataBase Reference | 5193-03-3(CAS DataBase Reference) |
| | 2-CHLORO-6-HYDRAZINOPYRIDINE Usage And Synthesis |
| Uses |
2-Chloro-6-hydrazinopyridine is used as a useful research chemical.
| | Synthesis | General procedure for the synthesis of 2-chloro-6-hydrazinopyridine from 2,6-dichloropyridine: 2,6-dichloropyridine (50.0 g, 0.34 mol) was dissolved in a solvent mixture of 80% hydrazine monohydrate solution (120 mL, 1.92 mol) and ethanol (200 mL), and heated and refluxed for 4 hours at 100 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm complete consumption of 2,6-dichloropyridine. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated to dryness in a rotary evaporator. The resulting crude product was purified by recrystallization from petroleum ether to afford 2-chloro-6-hydrazinopyridine (31.0 g, 64%) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.42 (dd, J = 7.2 Hz, 0.4 Hz, 1H), 6.65 (t, J = 7.2 Hz, 2H), 6.14 (s, 1H), 3.63 (s, 2H). | | References | [1] Organic and Biomolecular Chemistry, 2004, vol. 2, # 2, p. 246 - 256
[2] Patent: US2003/187014, 2003, A1
[3] Patent: WO2014/201127, 2014, A2. Location in patent: Paragraph 00582
[4] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2006, vol. 65, # 1, p. 206 - 214
[5] Patent: US4997835, 1991, A |
| | 2-CHLORO-6-HYDRAZINOPYRIDINE Preparation Products And Raw materials |
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