1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:AMG 579
CAS:1227067-61-9
Purity:99.35% Package:1mg;30USD|2mg;39USD|5mg;67USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone
CAS:1227067-61-9
Purity:34499% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:AMG-579
CAS:1227067-61-9
Purity:98% Package:5mg Remarks:V3461
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:AMG 579
CAS:1227067-61-9
Purity:99.35% Package:1mg;30USD|2mg;39USD|5mg;67USD
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:AMG 579
CAS:1227067-61-9
Purity:99% Package:$175.9/5mg;$275.9/10mg;$825.9/50mg;$1125.9/100mg;Bulk package Remarks:99%

1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone manufacturers

  • AMG 579
  • AMG 579 pictures
  • $30.00
  • 2026-05-11
  • CAS:1227067-61-9
  • Purity: 99.87%
  • Supply Ability: 10g
  • AMG 579
  • AMG 579 pictures
  • $30.00
  • 2026-05-11
  • CAS:1227067-61-9
  • Purity: 99.87%
  • Supply Ability: 10g
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Basic information
Product Name:1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone
Synonyms:1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone;Ethanone, 1-[4-[3-[4-(1H-benzimidazol-2-ylcarbonyl)phenoxy]-2-pyrazinyl]-1-piperidinyl]-;AMG 579, 10 mM in DMSO
CAS:1227067-61-9
MF:C25H23N5O3
MW:441.48
EINECS:
Product Categories:
Mol File:1227067-61-9.mol
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Structure
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Chemical Properties
Boiling point 689.9±65.0 °C(Predicted)
density 1.322±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 41.67 mg/mL (94.39 mM)
pka10.10±0.10(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Usage And Synthesis
UsesAMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.
in vivo

AMG 579 shows statistically significant reduction of PCP induced behavior in rats over the 2 h period. Minimum effective doses for efficacy in PCP-LMA model is determined to be 0.3 mg/kg for AMG 579. In dog, 5 exhibits superior oral bioavailability of 72%[1].

References[1] Hu E,et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). J Med Chem. 2014 Aug 14;57(15 DOI:10.1021/jm500713j
1-[4-[3-[4-(1H-benzimidazole-2-carbonyl)phenoxy]pyrazin-2-yl]piperidin-1-yl]ethanone Preparation Products And Raw materials
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