L-ALPHA-LYSOPHOSPHATIDYLCHOLINE manufacturers
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| | L-ALPHA-LYSOPHOSPHATIDYLCHOLINE Basic information |
| Product Name: | L-ALPHA-LYSOPHOSPHATIDYLCHOLINE | | Synonyms: | 3-SN-LYSOPHOSPHATIDYLCHOLINE;SOY TOTAL EXTRACT;SOY LYSO PC;SOY PC;L-α-Lysophosphatidylcholine from egg yolk ~99%, Type I, powder;L-A-LYSOPHOSPHATIDYLCHOLINE TYPE III*FRO M BOVINE LI;L-A-LYSOPHOSPHATIDYLCHOLINE TYPE V*FROM BOVINE BRAI;fromeggyolk | | CAS: | 9008-30-4 | | MF: | NULL | | MW: | 0 | | EINECS: | 232-715-0 | | Product Categories: | | | Mol File: | Mol File | ![L-ALPHA-LYSOPHOSPHATIDYLCHOLINE Structure]() |
| | L-ALPHA-LYSOPHOSPHATIDYLCHOLINE Chemical Properties |
| density | 1.47 g/mL at 20 °C(lit.) | | storage temp. | -20°C | | solubility | chloroform/methanol (9:1): 50 mg/mL, clear, colorless | | form | powder | | color | white | | biological source | soybean | | Cosmetic Ingredient Review (CIR) | L-ALPHA-LYSOPHOSPHATIDYLCHOLINE (9008-30-4) |
| | L-ALPHA-LYSOPHOSPHATIDYLCHOLINE Usage And Synthesis |
| Uses | L-α-Lysophosphatidylcholine from egg yolk has been used:
- as a surfactant
- as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
- as a demyelinating agent for nerve
- as a component in sperm nuclei preparation buffer
| | Uses | L-alpha-Lysophosphatidylcholine (from egg yolk) is a major component of oxidized low density lipoproteins that has been implicated in various inflammatory reactions. | | Definition | ChEBI: 1-acetyl-sn-glycero-3-phosphocholine is a 1-O-acyl-sn-glycero-3-phosphocholine. | | General Description | L-α-Lysophosphatidylcholine is a major plasma lipid, derived from phosphatidylcholines that includes glycerol and sphingoid based lipids with one fatty acid. It is an important cell signaling molecule for G-protein coupled receptors. | | Biochem/physiol Actions | L-α-Lysophosphatidylcholine possess cytotoxic effects and is present at high level in ischemia and atherosclerotic aortas. | | in vivo | Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) protects against sepsis-induced lethality on albino ICR mice[4].
Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) enhances bacterial clearance, blocks cecal ligation and puncture (CLP)-induced neutrophil deactivation and increases bactericidal activity of neutrophils[4]. | Animal Model: | Albino ICR mice [4] | | Dosage: | 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg | | Administration: | Oral | | Result: | Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg. |
| | IC 50 | IL-1β; ERK1; ERK2 |
| | L-ALPHA-LYSOPHOSPHATIDYLCHOLINE Preparation Products And Raw materials |
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