- DL-O-METHYLSERINE
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- $1.00 / 1KG
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2019-12-20
- CAS:19794-53-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | DL-O-METHYLSERINE Basic information |
| | DL-O-METHYLSERINE Chemical Properties |
| Boiling point | 260.6±30.0 °C(Predicted) | | density | 1.195±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | powder to crystal | | pka | 2.10±0.10(Predicted) | | color | White to Almost white | | CAS DataBase Reference | 19794-53-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2922500090 |
| | DL-O-METHYLSERINE Usage And Synthesis |
| Uses | O-Methylserine acts as a reagent for the synthesis of D-serine transporter inhibitors which are used pharmaceutically for the treatment of visual system disorders and enhancement of the visual functions. | | Definition | ChEBI: O-Methyl-DL-serine is an alpha-amino acid. | | Synthesis | 1) Add 215 g of methyl acrylate to the reaction flask. The temperature of the reaction system was raised to 55°C and 500 g of bromine was added slowly and dropwise. The reaction was maintained for 1 hour. Subsequently, concentration was carried out under reduced pressure at 60 °C to remove the excess bromine. To the residue was added 1260 g of methanol and the mixture was cooled to -17 °C. At this temperature, 127 g of sodium methanol was added and the reaction was carried out for 5.5 hours. Upon completion of the reaction, the methanol was removed by distillation under reduced pressure. 750 g of ammonia was added to the reaction mixture and the reaction was held at 20-25°C for 3 hours. Finally, 260 g of O-methyl-DL-serine was obtained by concentrated crystallization. | | References | [1] Patent: CN105949074, 2016, A. Location in patent: Paragraph 0041 |
| | DL-O-METHYLSERINE Preparation Products And Raw materials |
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