(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone

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(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Suppliers list
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(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone manufacturers

  • PF-06263276
  • PF-06263276 pictures
  • $92.00
  • 2026-07-27
  • CAS:1421502-62-6
  • Purity:
  • Supply Ability: 10g
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Basic information
Product Name:(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone
Synonyms:PF 6263276;PF-06263276 (PF 6263276);Methanone, [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(1-piperidinyl)-2-pyrazinyl]-;PF-06263276 >=98% (HPLC);PF06263276,PF 06263276;2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone;(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone
CAS:1421502-62-6
MF:C31H31FN8O2
MW:566.63
EINECS:
Product Categories:
Mol File:1421502-62-6.mol
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Structure
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Chemical Properties
Boiling point 921.1±65.0 °C(Predicted)
density 1.394±0.06 g/cm3(Predicted)
storage temp. room temp
solubility Soluble in DMSO
form powder
pka8.54±0.25(Predicted)
color white to beige
InChIKeyXDJGNPSZQSWJCV-UHFFFAOYSA-N
SMILESFC1=C(O)C=C(CC)C(C2=CC(NN=C3C4=NC5=C(CCN(C(C6=CN=C(N7CCCCC7)C=N6)=O)C5)N4)=C3C=C2)=C1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Usage And Synthesis
UsesPF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively. PF-06263276 inhibits pSTAT3 and TYK2 pathway. PF-06263276 has a protective effect against ear skin inflammation[1].
Biological ActivityPF-06263276 is an inhibitor of the Janus kinase (JAK) enzymes 1, 2, 3 and tyrosine kinase 2 (TYK2). PF-06263276 has been investigated for the treatment of psoriasis.
in vivo

PF-06263276 (0.3-100 μg/animal; i.t.) can dose-dependently inhibit the increase of lung pSTAT3 in the pharmacodynamic model of IL-6-induced lung pSTAT3 response in mice, with an ED50 of approximately 3 μg/animal[1].
PF-06263276 (4% solution; topical administration; multiple times; 11 days) can significantly reduce ear swelling by 48% in the IL-23-induced mouse ear skin inflammation model and inhibit the JAK2/TYK2 pathway[1].

IC 50JAK1: 2.2 nM (IC50); JAK2: 23.1 nM (IC50); JAK3: 59.9 nM (IC50); Tyk2: 29.7 nM (IC50)
References[1] Jones P, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786. DOI:10.1021/acs.jmedchem.6b01634
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone Preparation Products And Raw materials
Tag:(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone(1421502-62-6) Related Product Information
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