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- 2-methoxypyridine
-
-
2026-09-16
- CAS:1628-89-3
- Min. Order: 100gm
- Purity: 99%min
- Supply Ability: 100kgs
- 2-Methoxypyridine
-
- $2.20
-
2026-08-25
- CAS:1628-89-3
- Min. Order: 1kg
- Purity: 99%min
- Supply Ability: 1000kg
- 2-Methoxypyridine
-
- $1.10
-
2026-08-20
- CAS:1628-89-3
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
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| | 2-Methoxypyridine Basic information |
| | 2-Methoxypyridine Chemical Properties |
| Boiling point | 142 °C (lit.) | | density | 1.038 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.503(lit.) | | FEMA | 4639 | 2-METHOXYPYRIDINE | | Fp | 90 °F | | storage temp. | Inert atmosphere,Room Temperature | | form | Liquid | | pka | 3.28(at 20℃) | | color | Clear colorless to slightly yellow | | Appearance | Colorless to Light yellow clear liquid | | Odor | at 0.10%inpropylene glycol. green fermented tea | | Water Solubility | INSOLUBLE | | JECFA Number | 2156 | | BRN | 108189 | | InChI | 1S/C6H7NO/c1-8-6-4-2-3-5-7-6/h2-5H,1H3 | | InChIKey | IWTFOFMTUOBLHG-UHFFFAOYSA-N | | SMILES | COc1ccccn1 | | LogP | 1.32 | | CAS DataBase Reference | 1628-89-3(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, 2-methoxy-(1628-89-3) |
| Hazard Codes | Xi,F | | Risk Statements | 10-36/37/38 | | Safety Statements | 26-36-16 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29339900 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 2-Methoxypyridine Usage And Synthesis |
| Chemical Properties | Clear colorless to slightly yellow liquid | | Uses | 2-Methoxypyridine can be used as an intermediate to synthesize 2-methoxy-3-pyridinesulfonyl chloride which is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents. It can also be used to prepare bicyclic iminopyrimidinones as Beta Amyloid Cleaving Enzyme-1 (BACE1) inhibitors. | | Synthesis | CsSO4F may be used to fluorinate pyridine directly, but the reaction is very sensitive to the solvents employed. When solvents such as pentane and diethyl ether were used, 2-fluoropyridine was the major product, but use of nucleophilic solvents, such as methanol gave 2-methoxypyridine.
 | | References | [1] DAI W, LIU S, ZHANG Z, et al. Conformational preferences and isomerization upon excitation/ionization of 2-methoxypyridine and 2-N-methylaminopyridine†[J]. Physical Chemistry Chemical Physics, 2018, 9: 6211-6226. DOI:10.1039/C7CP07854D.
[2] Singh, Avtar, et al. "Synthesis of C-6 and C-3 substituted chalcogen derivatives of 2-methoxypyridine through lithiation of 2-methoxypyridine: An experimental and quantum chemical study." Inorganica Chimica Acta 432 (2015): 109-114.
[3] Trécourt, F., et al. "Catalyzed metalation applied to 2-methoxypyridine." The Journal of Organic Chemistry 53.7 (1988): 1367-1371.
[4] Ahipa, T. N., and Airody Vasudeva Adhikari. "2-Methoxypyridine derivatives: synthesis, liquid crystalline and photo-physical properties." New Journal of Chemistry 38.10 (2014): 5018-5029.
[5] WANYING CHENG . Conformation and bonding of 2-methoxypyridine and its monohydrate from rotational spectra[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 239: Article 118434. DOI:10.1016/j.saa.2020.118434. |
| | 2-Methoxypyridine Preparation Products And Raw materials |
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